WebFlucytosine is taken up within sensitive fungal cells by cytosine permease, which converts it to 5-fluorouracil. The 5-fluorouracil is then further metabolized to yield 5-fluorodeoxyuridine monophosphate, a competitive inhibitor of thymidylate synthetase. The formation of thymidine monophosphate from deoxyuridine monophosphate is thus blocked ... WebFlucytosine is an antimetabolite that acts as an antifungal agent with in vitro and in vivo activity against Candida and Cryptococcus. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits ...
Saccharomyces cerevisiae salvage pathways of pyrimidine …
WebFlucytosine is taken up by fungal cells via the enzyme cytosine permease. It is converted intracellularly first to 5-FU and then to 5- fluorodeoxyuridine monophosphate … Web"The purine-cytosine permease gene of Saccharomyces cerevisiae: primary structure and deduced protein sequence of the FCY2 gene product." Mol Microbiol 4(4);585-96. PMID: 2191181. Yao05: Yao L, Li Y, Wu Y, Liu A, Yan H (2005). "Product release is rate-limiting in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase." how do i find my homes value
The immunodetected yeast purine—cytosine permease is not …
WebPTHR31806 PURINE-CYTOSINE PERMEASE FCY2-RELATED 1 hit; PIRSF. PIRSF002744 Pur-cyt_permease 1 hit; Pfam. View protein in Pfam; PF02133 … Webthe yeast uracil permease FUR4 (Jund et al., 1988; Galan et al., 1996; Marchal et al., 1998). As a first step toward identifying transporters for nucleic acid bases and their derivatives, such as cytokinins or sec? ondary metabolites, the purine-cytosine transport?defi? cient yeast mutant 1cy2 was used to clone plant transporter WebJul 17, 2006 · A genome-wide search for cytosine permease homologues identified two uncharacterized candidate genes, designated FCY21 and FCY22, both of which exhibit … how much is shipping from china